ABOUT PEER-REVIEWED SCIENCE

Mannatech’s Research Group devotes extensive resources to pre-clinical and clinical testing of products and product ingredients. In this section, you will learn about publications that report the results of these studies. When possible, complete publications are provided. Our intent is to make you aware of available science, but remember that this information is intended to be educational and should not be construed as product claims. Mannatech product claims can be found on www.new.mannatech.com.

As you read these studies, we encourage you to keep in mind the following:

Q. Is the study you are reading a poster or an abstract from a scientific meeting, or was it published in a peer-reviewed journal?
A. While posters or abstracts are peer-reviewed, articles published in peer-reviewed journals provide stronger scientific evidence because they are subjected to much stricter standards before they are published.

Q. Is the study about an ingredient in a product, or is it about the product itself?
A. While an ingredient study provides valuable information, it doesn’t necessarily mean that a product containing that ingredient will have exactly the same effect.

Q. Are you reading a chemistry, in vitro (test tube), animal, or human study?
A. Chemistry studies provide data about the composition of an ingredient or a product. In vitro studies, typically using specific types of cells that have been isolated from the tissues of living people or animals, give an early indication of effects an ingredient or product will be expected to have in animals or humans.

Animal studies give a more advanced, early indication of the effect the product will be expected to have in humans.

In human interventional clinical trials, the investigator (doctor conducting the study) controls whether the subject receives the product and in what amounts. Normally, these studies are conducted with controls (i.e. a group of people with the same health status that do not take the products). This allows for comparison of the product's effects among those people taking the product and those not taking it. In general, interventional studies provide the strongest evidence for a product's effectiveness.

In double-blind, placebo-controlled clinical trials, subjects take either the product that is the subject of the investigation or a placebo. "Double-blind" means that neither the doctor responsible for the study nor the subjects taking the product knows who is taking the product and who is taking the placebo. This helps eliminate investigator bias in reporting trial results. In general, double-blind, placebo-controlled clinical trials are the highest standard for interventional studies and provide the strongest evidence for a product's effectiveness.